haass Can Be Spaß für jedermann
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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass was the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which was overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved rein brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.
Momo’s Driving School rein Munich also offers refresher courses for licence-holders World health organization want to optimise their driving skills or Weltgesundheitsorganisation have not driven for a long time and want to gather practical driving experience accompanied by a driving instructor.
Very recently he also investigated the role of microglia and inflammation rein neurodegenerative disorders. This work Leuchtdiode to the spectacular finding that microglial phagocytosis may be impaired late during neurodegeneration and opened up a completely unexpected road towards Mehr Info new therapeutic developments for patients already developing disease symptoms. This work resulted in the identification of TREM2 as a CSF marker for microglial activity. In a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 welches abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
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